2r5u

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{{STRUCTURE_2r5u| PDB=2r5u | SCENE= }}
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'''Crystal structure of the N-terminal domain of DnaB helicase from Mycobacterium tuberculosis'''
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===Crystal structure of the N-terminal domain of DnaB helicase from Mycobacterium tuberculosis===
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==Overview==
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Hexameric DnaB helicase unwinds the DNA double helix during replication of genetic material in bacteria. DnaB is an essential bacterial protein; therefore, it is an important potential target for antibacterial drug discovery. We report a crystal structure of the N-terminal region of DnaB from the pathogen Mycobacterium tuberculosis (MtDnaBn), determined at 2.0 A resolution. This structure provides atomic resolution details of formation of the hexameric ring of DnaB by two distinct interfaces. An extensive hydrophobic interface stabilizes a dimer of MtDnaBn by forming a four-helix bundle. The other, less extensive, interface is formed between the dimers, connecting three of them into a hexameric ring. On the basis of crystal packing interactions between MtDnaBn rings, we suggest a model of a helicase-primase complex that explains previously observed effects of DnaB mutations on DNA priming.
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==About this Structure==
==About this Structure==
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[[Category: Protein splicing]]
[[Category: Protein splicing]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:14:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:58:59 2008''

Revision as of 15:59, 27 July 2008

Image:2r5u.png

Template:STRUCTURE 2r5u

Crystal structure of the N-terminal domain of DnaB helicase from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 18479467

About this Structure

2R5U is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase., Biswas T, Tsodikov OV, FEBS J. 2008 Jun;275(12):3064-71. Epub 2008 May 8. PMID:18479467

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