We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2r5u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2r5u", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:2r5u.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2r5u.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2r5u| PDB=2r5u | SCENE= }}
{{STRUCTURE_2r5u| PDB=2r5u | SCENE= }}
-
'''Crystal structure of the N-terminal domain of DnaB helicase from Mycobacterium tuberculosis'''
+
===Crystal structure of the N-terminal domain of DnaB helicase from Mycobacterium tuberculosis===
-
==Overview==
+
<!--
-
Hexameric DnaB helicase unwinds the DNA double helix during replication of genetic material in bacteria. DnaB is an essential bacterial protein; therefore, it is an important potential target for antibacterial drug discovery. We report a crystal structure of the N-terminal region of DnaB from the pathogen Mycobacterium tuberculosis (MtDnaBn), determined at 2.0 A resolution. This structure provides atomic resolution details of formation of the hexameric ring of DnaB by two distinct interfaces. An extensive hydrophobic interface stabilizes a dimer of MtDnaBn by forming a four-helix bundle. The other, less extensive, interface is formed between the dimers, connecting three of them into a hexameric ring. On the basis of crystal packing interactions between MtDnaBn rings, we suggest a model of a helicase-primase complex that explains previously observed effects of DnaB mutations on DNA priming.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18479467}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18479467 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18479467}}
==About this Structure==
==About this Structure==
Line 39: Line 43:
[[Category: Protein splicing]]
[[Category: Protein splicing]]
[[Category: Replication]]
[[Category: Replication]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:14:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:58:59 2008''

Revision as of 15:59, 27 July 2008

Image:2r5u.png

Template:STRUCTURE 2r5u

Crystal structure of the N-terminal domain of DnaB helicase from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 18479467

About this Structure

2R5U is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase., Biswas T, Tsodikov OV, FEBS J. 2008 Jun;275(12):3064-71. Epub 2008 May 8. PMID:18479467

Page seeded by OCA on Sun Jul 27 18:58:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r5u"
Personal tools