This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2qfb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2qfb.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2qfb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2qfb| PDB=2qfb | SCENE= }}
{{STRUCTURE_2qfb| PDB=2qfb | SCENE= }}
-
'''Crystal structure of the regulatory domain of human RIG-I with bound Zn'''
+
===Crystal structure of the regulatory domain of human RIG-I with bound Zn===
-
==Overview==
+
<!--
-
The ATPase RIG-I senses viral RNAs that contain 5'-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by interferon and cytokine production, providing essential antiviral protection for the host. The mode of RNA 5'-triphosphate sensing by RIG-I remains elusive. We show that the C-terminal regulatory domain RD of RIG-I binds viral RNA in a 5'-triphosphate-dependent manner and activates the RIG-I ATPase by RNA-dependent dimerization. The crystal structure of RD reveals a zinc-binding domain that is structurally related to GDP/GTP exchange factors of Rab-like GTPases. The zinc coordination site is essential for RIG-I signaling and is also conserved in MDA5 and LGP2, suggesting related RD domains in all three enzymes. Structure-guided mutagenesis identifies a positively charged groove as likely 5'-triphosphate-binding site of RIG-I. This groove is distinct in MDA5 and LGP2, raising the possibility that RD confers ligand specificity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18243112}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18243112 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18243112}}
==About this Structure==
==About this Structure==
Line 39: Line 43:
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:51:28 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:00:20 2008''

Revision as of 16:00, 27 July 2008

Image:2qfb.png

Template:STRUCTURE 2qfb

Crystal structure of the regulatory domain of human RIG-I with bound Zn

Template:ABSTRACT PUBMED 18243112

About this Structure

2QFB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I., Cui S, Eisenacher K, Kirchhofer A, Brzozka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP, Mol Cell. 2008 Feb 1;29(2):169-179. PMID:18243112

Page seeded by OCA on Sun Jul 27 19:00:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qfb"
Personal tools