1q5f

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{{STRUCTURE_1q5f| PDB=1q5f | SCENE= }}
{{STRUCTURE_1q5f| PDB=1q5f | SCENE= }}
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'''NMR Structure of Type IVb pilin (PilS) from Salmonella typhi'''
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===NMR Structure of Type IVb pilin (PilS) from Salmonella typhi===
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==Overview==
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The structure of the N-terminal-truncated Type IVb structural pilin (t-PilS) from Salmonella typhi was determined by NMR. Although topologically similar to the recently determined x-ray structure of pilin from Vibrio cholerae toxin-coregulated pilus, the only Type IVb pilin with known structure, t-PilS contains many distinct structural features. The protein contains an extra pair of beta-strands in the N-terminal alphabeta loop that align with the major beta-strands to form a continuous 7-stranded antiparallel beta-sheet. The C-terminal disulfide-bonded region of t-PilS is only half the length of that of toxin-coregulated pilus pilin. A model of S. typhi pilus has been proposed and mutagenesis studies suggested that residues on both the alphabeta loop and the C-terminal disulfide-bonded region of PilS might be involved in binding specificity of the pilus. This model structure reveals an exposed surface between adjacent subunits of PilS that could be a potential binding site for the cystic fibrosis transmembrane conductance regulator.
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{{ABSTRACT_PUBMED_15159389}}
==About this Structure==
==About this Structure==
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1Q5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhi Salmonella typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA].
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1Q5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhi Salmonella typhi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA].
==Reference==
==Reference==
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[[Category: Monomer]]
[[Category: Monomer]]
[[Category: Type ivb pilin]]
[[Category: Type ivb pilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:53:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:03:25 2008''

Revision as of 16:03, 27 July 2008

Image:1q5f.png

Template:STRUCTURE 1q5f

NMR Structure of Type IVb pilin (PilS) from Salmonella typhi

Template:ABSTRACT PUBMED 15159389

About this Structure

1Q5F is a Single protein structure of sequence from Salmonella typhi. Full experimental information is available from OCA.

Reference

NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus., Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK, J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:15159389

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