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2c7c

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[[Image:2c7c.gif|left|200px]]
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{{Seed}}
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[[Image:2c7c.png|left|200px]]
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{{STRUCTURE_2c7c| PDB=2c7c | SCENE= }}
{{STRUCTURE_2c7c| PDB=2c7c | SCENE= }}
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'''FITTED COORDINATES FOR GROEL-ATP7-GROES CRYO-EM COMPLEX (EMD-1180)'''
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===FITTED COORDINATES FOR GROEL-ATP7-GROES CRYO-EM COMPLEX (EMD-1180)===
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==Overview==
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The double-ring chaperonin GroEL and its lid-like cochaperonin GroES form asymmetric complexes that, in the ATP-bound state, mediate productive folding in a hydrophilic, GroES-encapsulated chamber, the so-called cis cavity. Upon ATP hydrolysis within the cis ring, the asymmetric complex becomes able to accept non-native polypeptides and ATP in the open, trans ring. Here we have examined the structural basis for this allosteric switch in activity by cryo-EM and single-particle image processing. ATP hydrolysis does not change the conformation of the cis ring, but its effects are transmitted through an inter-ring contact and cause domain rotations in the mobile trans ring. These rigid-body movements in the trans ring lead to disruption of its intra-ring contacts, expansion of the entire ring and opening of both the nucleotide pocket and the substrate-binding domains, admitting ATP and new substrate protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_16429154}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16429154 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16429154}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:22:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:07:19 2008''

Revision as of 16:07, 27 July 2008

Image:2c7c.png

Template:STRUCTURE 2c7c

FITTED COORDINATES FOR GROEL-ATP7-GROES CRYO-EM COMPLEX (EMD-1180)

Template:ABSTRACT PUBMED 16429154

About this Structure

2C7C is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes., Ranson NA, Clare DK, Farr GW, Houldershaw D, Horwich AL, Saibil HR, Nat Struct Mol Biol. 2006 Feb;13(2):147-52. Epub 2006 Jan 22. PMID:16429154

Page seeded by OCA on Sun Jul 27 19:07:19 2008

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