We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1ww7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ww7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ww7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ww7| PDB=1ww7 | SCENE= }}
{{STRUCTURE_1ww7| PDB=1ww7 | SCENE= }}
-
'''Agrocybe cylindracea galectin (Ligand-free)'''
+
===Agrocybe cylindracea galectin (Ligand-free)===
-
==Overview==
+
<!--
-
Galectin from an edible fungus Agrocybe cylindracea (ACG) has a strong preference for N-acetylneuraminyl lactose (NeuAcalpha2-3lactose). The sugar recognition mechanism of ACG was explored by the X-ray crystallographic analyses of ligand-free ACG, and its complex with lactose, 3'-sulfonyl lactose and NeuAcalpha2-3lactose. The refined structure shows that ACG is a "proto"-type galectin composed of a beta-sandwich of two antiparallel sheets, each with six strands, in contrast to the five and six strands in animal galectins. ACG dimer in solution was classified as being among the "layer"-type. The carbohydrate recognition domain (CRD) of this galectin is common to those of animal galectins, except for substitution of one residue, Ala64, which corresponds to Asn46 in human galectin 1. A five-residue insertion in ACG at positions 42-46 involving Ser44 and Asn46 modified the architecture of the sugar binding site that contributes sialic acid specificity. Furthermore, it was found that the binding of a sulfate ion near the CRD in the ligand-free form led to a change in the conformation of the loop region caused by main-chain cis/trans transition between Ser44 and Pro45.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16051274}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16051274 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16051274}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Fungal galectin]]
[[Category: Fungal galectin]]
[[Category: Sulfate ion]]
[[Category: Sulfate ion]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:13:09 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:07:39 2008''

Revision as of 16:07, 27 July 2008

Image:1ww7.png

Template:STRUCTURE 1ww7

Agrocybe cylindracea galectin (Ligand-free)

Template:ABSTRACT PUBMED 16051274

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of a fungal galectin from Agrocybe cylindracea for recognizing sialoconjugate., Ban M, Yoon HJ, Demirkan E, Utsumi S, Mikami B, Yagi F, J Mol Biol. 2005 Aug 26;351(4):695-706. PMID:16051274

Page seeded by OCA on Sun Jul 27 19:07:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ww7"
Personal tools