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2p2c

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[[Image:2p2c.gif|left|200px]]
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{{STRUCTURE_2p2c| PDB=2p2c | SCENE= }}
{{STRUCTURE_2p2c| PDB=2p2c | SCENE= }}
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'''Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin)'''
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===Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin)===
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==Overview==
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Specific and potent caspase inhibitors are indispensable for the dissection of the intricate pathways leading to apoptosis. We selected a designed ankyrin repeat protein (DARPin) from a combinatorial library that inhibits caspase-2 in vitro with a subnanomolar inhibition constant and, in contrast to the peptidic caspase inhibitors, with very high specificity for this particular caspase. The crystal structure of this inhibitor (AR_F8) in complex with caspase-2 reveals the molecular basis for the specificity and, together with kinetic analyses, the allosteric mechanism of inhibition. The structure also shows a conformation of the active site that can be exploited for the design of inhibitory compounds. AR_F8 is a specific inhibitor of an initiator caspase and has the potential to help identify the function of caspase-2 in the complex biological apoptotic signaling network.
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(as it appears on PubMed at http://www.pubmed.gov), where 17502107 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17502107}}
==About this Structure==
==About this Structure==
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[[Category: Protein library]]
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[[Category: Ribosome display]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:11:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:08:02 2008''

Revision as of 16:08, 27 July 2008

Image:2p2c.png

Template:STRUCTURE 2p2c

Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin)

Template:ABSTRACT PUBMED 17502107

About this Structure

2P2C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism., Schweizer A, Roschitzki-Voser H, Amstutz P, Briand C, Gulotti-Georgieva M, Prenosil E, Binz HK, Capitani G, Baici A, Pluckthun A, Grutter MG, Structure. 2007 May;15(5):625-36. PMID:17502107

Page seeded by OCA on Sun Jul 27 19:08:02 2008

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