1y39

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{{STRUCTURE_1y39| PDB=1y39 | SCENE= }}
{{STRUCTURE_1y39| PDB=1y39 | SCENE= }}
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'''Co-evolution of protein and RNA structures within a highly conserved ribosomal domain'''
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===Co-evolution of protein and RNA structures within a highly conserved ribosomal domain===
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==Overview==
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The X-ray crystal structure of a ribosomal L11-rRNA complex with chloroplast-like mutations in both protein and rRNA is presented. The global structure is almost identical to that of the wild-type (bacterial) complex, with only a small movement of the protein alpha helix away from the surface of the RNA required to accommodate the altered protein residue. In contrast, the specific hydrogen bonding pattern of the mutated residues is substantially different, and now includes a direct interaction between the protein side chain and an RNA base edge and a water-mediated contact. Comparison of the two structures allows the observations of sequence variation and relative affinities of wild-type and mutant complexes to be clearly rationalized, but reinforces the concept that there is no single simple code for protein-RNA recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 15734647 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15734647}}
==About this Structure==
==About this Structure==
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[[Category: Rrna]]
[[Category: Rrna]]
[[Category: X-ray crystal structure]]
[[Category: X-ray crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:49:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:11:30 2008''

Revision as of 16:11, 27 July 2008

Image:1y39.png

Template:STRUCTURE 1y39

Co-evolution of protein and RNA structures within a highly conserved ribosomal domain

Template:ABSTRACT PUBMED 15734647

About this Structure

1Y39 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Coevolution of protein and RNA structures within a highly conserved ribosomal domain., Dunstan MS, Guhathakurta D, Draper DE, Conn GL, Chem Biol. 2005 Feb;12(2):201-6. PMID:15734647

Page seeded by OCA on Sun Jul 27 19:11:30 2008

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