2oew

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[[Image:2oew.gif|left|200px]]
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{{Seed}}
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[[Image:2oew.png|left|200px]]
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{{STRUCTURE_2oew| PDB=2oew | SCENE= }}
{{STRUCTURE_2oew| PDB=2oew | SCENE= }}
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'''Structure of ALIX/AIP1 Bro1 Domain'''
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===Structure of ALIX/AIP1 Bro1 Domain===
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==Overview==
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ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX(n)L late-domain motifs (X = any residue; n = 1-3). Crystal structures reveal that human ALIX is composed of an N-terminal Bro1 domain and a central domain that is composed of two extended three-helix bundles that form elongated arms that fold back into a "V." The structures also reveal conformational flexibility in the arms that suggests that the V domain may act as a flexible hinge in response to ligand binding. YPX(n)L late domains bind in a conserved hydrophobic pocket on the second arm near the apex of the V, whereas CHMP4/ESCRT-III proteins bind a conserved hydrophobic patch on the Bro1 domain, and both interactions are required for virus budding. ALIX therefore serves as a flexible, extended scaffold that connects retroviral Gag proteins to ESCRT-III and other cellular-budding machinery.
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The line below this paragraph, {{ABSTRACT_PUBMED_17350572}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17350572 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17350572}}
==About this Structure==
==About this Structure==
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[[Category: Tetratricopeptide repeat]]
[[Category: Tetratricopeptide repeat]]
[[Category: Tpr]]
[[Category: Tpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:45:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:11:53 2008''

Revision as of 16:11, 27 July 2008

Image:2oew.png

Template:STRUCTURE 2oew

Structure of ALIX/AIP1 Bro1 Domain

Template:ABSTRACT PUBMED 17350572

About this Structure

2OEW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding., Fisher RD, Chung HY, Zhai Q, Robinson H, Sundquist WI, Hill CP, Cell. 2007 Mar 9;128(5):841-52. PMID:17350572

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