1wap

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[[Image:1wap.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1wap| PDB=1wap | SCENE= }}
{{STRUCTURE_1wap| PDB=1wap | SCENE= }}
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'''TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN'''
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===TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN===
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==Overview==
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The crystal structure of the trp RNA-binding attenuation protein of Bacclius subtilis solved at 1.8 A resolution reveals a novel structural arrangement in which the eleven subunits are stabilized through eleven intersubunit beta-sheets to form a beta-wheel with a large central hole. The nature of the binding of L-tryptophan in clefts between adjacent beta-sheets in the beta-wheel suggests that this binding induces conformational changes in the flexible residues 25-33 and 49-52. It is argued that upon binding, the messenger RNA target forms a matching circle in which eleven U/GAG repeats are bound to the surface of the protein ondecamer modified by the binding of L-tryptophan.
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The line below this paragraph, {{ABSTRACT_PUBMED_7715723}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7715723 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7715723}}
==About this Structure==
==About this Structure==
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[[Category: Bacillus subtili]]
[[Category: Bacillus subtili]]
[[Category: Trp operon]]
[[Category: Trp operon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:23:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:12:38 2008''

Revision as of 16:12, 27 July 2008

Image:1wap.png

Template:STRUCTURE 1wap

TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN

Template:ABSTRACT PUBMED 7715723

About this Structure

1WAP is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The structure of trp RNA-binding attenuation protein., Antson AA, Otridge J, Brzozowski AM, Dodson EJ, Dodson GG, Wilson KS, Smith TM, Yang M, Kurecki T, Gollnick P, Nature. 1995 Apr 20;374(6524):693-700. PMID:7715723

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