1wkr

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{{STRUCTURE_1wkr| PDB=1wkr | SCENE= }}
{{STRUCTURE_1wkr| PDB=1wkr | SCENE= }}
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'''Crystal structure of aspartic proteinase from Irpex lacteus'''
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===Crystal structure of aspartic proteinase from Irpex lacteus===
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==Overview==
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The crystal structure of Irpex lacteus aspartic proteinase (ILAP) in complex with pepstatin (a six amino acid residue peptide-like inhibitor) was determined at 1.3A resolution. ILAP is a pepsin-like enzyme, widely distributed in nature, with high milk-clotting activity relative to proteolytic activity. The overall structure was in good topological agreement with pepsin and other aspartic proteases. The structure and interaction pattern around the catalytic site were conserved, in agreement with the other aspartic proteinase/inhibitor complex structures reported previously. The high-resolution data also supported the transition state model, as proposed previously for the catalytic mechanism of aspartic proteinase. Unlike the other aspartic proteinases, ILAP was found to require hydrophobic residues either in the P(1) or P(1') site, and also in the P(4) and/or P(3) site(s) for secondary interactions. The inhibitor complex structure also revealed the substrate binding mechanism of ILAP at the P(3) and P(4) site of the substrate, where the inserted loop built up the unique hydrophobic pocket at the P(4) site.
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(as it appears on PubMed at http://www.pubmed.gov), where 15321718 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15321718}}
==About this Structure==
==About this Structure==
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[[Category: Mizuno, H.]]
[[Category: Mizuno, H.]]
[[Category: Enzyme-inhibitor complex]]
[[Category: Enzyme-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:48:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:13:37 2008''

Revision as of 16:13, 27 July 2008

Image:1wkr.png

Template:STRUCTURE 1wkr

Crystal structure of aspartic proteinase from Irpex lacteus

Template:ABSTRACT PUBMED 15321718

About this Structure

1WKR is a Single protein structure of sequence from Irpex lacteus. Full crystallographic information is available from OCA.

Reference

Crystal structure of aspartic proteinase from Irpex lacteus in complex with inhibitor pepstatin., Fujimoto Z, Fujii Y, Kaneko S, Kobayashi H, Mizuno H, J Mol Biol. 2004 Aug 27;341(5):1227-35. PMID:15321718

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