1s9s

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[[Image:1s9s.gif|left|200px]]
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{{Seed}}
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[[Image:1s9s.png|left|200px]]
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{{STRUCTURE_1s9s| PDB=1s9s | SCENE= }}
{{STRUCTURE_1s9s| PDB=1s9s | SCENE= }}
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'''SOLUTION STRUCTURE OF MLV PSI SITE'''
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===SOLUTION STRUCTURE OF MLV PSI SITE===
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==Overview==
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The full length, positive-strand genome of the Moloney Murine Leukemia Virus contains a "core encapsidation signal" that is essential for efficient genome packaging during virus assembly. We have determined the structure of a 101-nucleotide RNA that contains this signal (called mPsi) using a novel isotope-edited NMR approach. The method is robust and should be generally applicable to larger RNAs. mPsi folds into three stem loops, two of which (SL-C and SL-D) co-stack to form an extended helix. The third stem loop (SL-B) is connected to SL-C by a flexible, four-nucleotide linker. The structure contains five mismatched base-pairs, an unusual C.CG base-triple platform, and a novel "A-minor K-turn," in which unpaired adenosine bases A340 and A341 of a GGAA bulge pack in the minor groove of a proximal stem, and a bulged distal uridine (U319) forms a hydrogen bond with the phosphodiester of A341. Phylogenetic analyses indicate that these essential structural elements are conserved among the murine C-type retroviruses.
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The line below this paragraph, {{ABSTRACT_PUBMED_15003457}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15003457 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15003457}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9S OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9S OCA].
==Reference==
==Reference==
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[[Category: Stem loop]]
[[Category: Stem loop]]
[[Category: U-u mismatch]]
[[Category: U-u mismatch]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:27:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:13:59 2008''

Revision as of 16:14, 27 July 2008

Image:1s9s.png

Template:STRUCTURE 1s9s

SOLUTION STRUCTURE OF MLV PSI SITE

Template:ABSTRACT PUBMED 15003457

About this Structure

Full experimental information is available from OCA.

Reference

NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus., D'Souza V, Dey A, Habib D, Summers MF, J Mol Biol. 2004 Mar 19;337(2):427-42. PMID:15003457

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