We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1s3o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1s3o.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1s3o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1s3o| PDB=1s3o | SCENE= }}
{{STRUCTURE_1s3o| PDB=1s3o | SCENE= }}
-
'''Human mitochondrial single strand DNA binding protein (hmSSB)'''
+
===Human mitochondrial single strand DNA binding protein (hmSSB)===
-
==Overview==
+
<!--
-
The Protein Data Bank (PDB) is the single most important repository of structural data for proteins and other biologically relevant molecules. Therefore, it is critically important to keep the PDB data, as much as possible, error-free. In this study, we have analyzed PDB crystal structures possessing oligonucleotide/oligosaccharide binding (OB)-fold, one of the highly populated folds, for the presence of sequence-structure mapping errors. Using energy-based structure quality assessment coupled with sequence analyses, we have found that there are at least five OB-structures in the PDB that have regions where sequences have been incorrectly mapped onto the structure. We have demonstrated that the combination of these computation techniques is effective not only in detecting sequence-structure mapping errors, but also in providing guidance to correct them. Namely, we have used results of computational analysis to direct a revision of X-ray data for one of the PDB entries containing a fairly inconspicuous sequence-structure mapping error. The revised structure has been deposited with the PDB. We suggest use of computational energy assessment and sequence analysis techniques to facilitate structure determination when homologs having known structure are available to use as a reference. Such computational analysis may be useful in either guiding the sequence-structure assignment process or verifying the sequence mapping within poorly defined regions.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15133161}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15133161 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15133161}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Venclovas, C.]]
[[Category: Venclovas, C.]]
[[Category: Ob fold]]
[[Category: Ob fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:15:30 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:15:08 2008''

Revision as of 16:15, 27 July 2008

Image:1s3o.png

Template:STRUCTURE 1s3o

Human mitochondrial single strand DNA binding protein (hmSSB)

Template:ABSTRACT PUBMED 15133161

About this Structure

1S3O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Sequence-structure mapping errors in the PDB: OB-fold domains., Venclovas C, Ginalski K, Kang C, Protein Sci. 2004 Jun;13(6):1594-602. Epub 2004 May 7. PMID:15133161

Page seeded by OCA on Sun Jul 27 19:15:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s3o"
Personal tools