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2a11

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{{STRUCTURE_2a11| PDB=2a11 | SCENE= }}
{{STRUCTURE_2a11| PDB=2a11 | SCENE= }}
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'''Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis'''
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===Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis===
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==Overview==
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RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs.
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(as it appears on PubMed at http://www.pubmed.gov), where 16155207 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16155207}}
==About this Structure==
==About this Structure==
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[[Category: Rnase iii]]
[[Category: Rnase iii]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:28:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:16:09 2008''

Revision as of 16:16, 27 July 2008

Image:2a11.png

Template:STRUCTURE 2a11

Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis

Template:ABSTRACT PUBMED 16155207

About this Structure

2A11 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207

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