1y00

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[[Image:1y00.gif|left|200px]]
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{{STRUCTURE_1y00| PDB=1y00 | SCENE= }}
{{STRUCTURE_1y00| PDB=1y00 | SCENE= }}
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'''Solution structure of the Carbon Storage Regulator protein CsrA'''
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===Solution structure of the Carbon Storage Regulator protein CsrA===
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==Overview==
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The carbon storage regulator A (CsrA) is a protein responsible for the repression of a variety of stationary-phase genes in bacteria. In this work, we describe the nuclear magnetic resonance (NMR)-based structure of the CsrA dimer and its RNA-binding properties. CsrA is a dimer of two identical subunits, each composed of five strands, a small alpha-helix and a flexible C terminus. NMR titration experiments suggest that the beta1-beta2 and beta3-beta4 loops and the C-terminal helix are important elements in RNA binding. Even though the beta3-beta4 loop contains a highly conserved RNA-binding motif, GxxG, typical of KH domains, our structure excludes CsrA from being a member of this protein family, as previously suggested. A mechanism for the recognition of mRNAs downregulated by CsrA is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15866937 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15866937}}
==About this Structure==
==About this Structure==
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1Y00 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA].
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1Y00 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA].
==Reference==
==Reference==
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
[[Category: Montreal-kingston bacterial structural genomics initiative]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:42:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:18:25 2008''

Revision as of 16:18, 27 July 2008

Image:1y00.png

Template:STRUCTURE 1y00

Solution structure of the Carbon Storage Regulator protein CsrA

Template:ABSTRACT PUBMED 15866937

About this Structure

1Y00 is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the carbon storage regulator protein CsrA from Escherichia coli., Gutierrez P, Li Y, Osborne MJ, Pomerantseva E, Liu Q, Gehring K, J Bacteriol. 2005 May;187(10):3496-501. PMID:15866937

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