1wco

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[[Image:1wco.gif|left|200px]]
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{{STRUCTURE_1wco| PDB=1wco | SCENE= }}
{{STRUCTURE_1wco| PDB=1wco | SCENE= }}
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'''THE SOLUTION STRUCTURE OF THE NISIN-LIPID II COMPLEX'''
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===THE SOLUTION STRUCTURE OF THE NISIN-LIPID II COMPLEX===
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==Overview==
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The emerging antibiotics-resistance problem has underlined the urgent need for novel antimicrobial agents. Lantibiotics (lanthionine-containing antibiotics) are promising candidates to alleviate this problem. Nisin, a member of this family, has a unique pore-forming activity against bacteria. It binds to lipid II, the essential precursor of cell wall synthesis. As a result, the membrane permeabilization activity of nisin is increased by three orders of magnitude. Here we report the solution structure of the complex of nisin and lipid II. The structure shows a novel lipid II-binding motif in which the pyrophosphate moiety of lipid II is primarily coordinated by the N-terminal backbone amides of nisin via intermolecular hydrogen bonds. This cage structure provides a rationale for the conservation of the lanthionine rings among several lipid II-binding lantibiotics. The structure of the pyrophosphate cage offers a template for structure-based design of novel antibiotics.
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(as it appears on PubMed at http://www.pubmed.gov), where 15361862 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15361862}}
==About this Structure==
==About this Structure==
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1WCO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis] and [http://en.wikipedia.org/wiki/Monarthropalpus_flavus Monarthropalpus flavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uzt 1uzt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCO OCA].
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1WCO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis] and [http://en.wikipedia.org/wiki/Monarthropalpus_flavus Monarthropalpus flavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uzt 1uzt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCO OCA].
==Reference==
==Reference==
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[[Category: Pore formation]]
[[Category: Pore formation]]
[[Category: Pyrophosphate cage]]
[[Category: Pyrophosphate cage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:28:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:19:04 2008''

Revision as of 16:19, 27 July 2008

Image:1wco.png

Template:STRUCTURE 1wco

THE SOLUTION STRUCTURE OF THE NISIN-LIPID II COMPLEX

Template:ABSTRACT PUBMED 15361862

About this Structure

1WCO is a Single protein structure of sequence from Lactococcus lactis and Monarthropalpus flavus. This structure supersedes the now removed PDB entry 1uzt. Full experimental information is available from OCA.

Reference

The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics., Hsu ST, Breukink E, Tischenko E, Lutters MA, de Kruijff B, Kaptein R, Bonvin AM, van Nuland NA, Nat Struct Mol Biol. 2004 Oct;11(10):963-7. Epub 2004 Sep 12. PMID:15361862

Page seeded by OCA on Sun Jul 27 19:19:04 2008

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