2hha

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[[Image:2hha.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2hha| PDB=2hha | SCENE= }}
{{STRUCTURE_2hha| PDB=2hha | SCENE= }}
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'''The structure of DPP4 in complex with an oxadiazole inhibitor'''
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===The structure of DPP4 in complex with an oxadiazole inhibitor===
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==Overview==
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A novel series of oxadiazole based amides have been shown to be potent DPP-4 inhibitors. The optimized compound 43 exhibited excellent selectivity over a variety of DPP-4 homologs.
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The line below this paragraph, {{ABSTRACT_PUBMED_16919457}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16919457 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16919457}}
==About this Structure==
==About this Structure==
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[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:17:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:20:40 2008''

Revision as of 16:20, 27 July 2008

Template:STRUCTURE 2hha

The structure of DPP4 in complex with an oxadiazole inhibitor

Template:ABSTRACT PUBMED 16919457

About this Structure

2HHA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors., Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE, Bioorg Med Chem Lett. 2006 Oct 15;16(20):5373-7. Epub 2006 Aug 17. PMID:16919457

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