1vyo

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[[Image:1vyo.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1vyo| PDB=1vyo | SCENE= }}
{{STRUCTURE_1vyo| PDB=1vyo | SCENE= }}
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'''CRYSTAL STRUCTURE OF AVIDIN'''
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===CRYSTAL STRUCTURE OF AVIDIN===
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==Overview==
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The chicken genome encodes several biotin-binding proteins, including avidin and avidin-related protein 4 (AVR4). In addition to D-biotin, avidin binds an azo dye compound, 4-hydroxyazobenzene-2-carboxylic acid (HABA), but the HABA-binding properties of AVR4 are not yet known. Differential scanning calorimetry, UV/visible spectroscopy, and molecular modeling were used to analyze the binding of 15 azo molecules to avidin and AVR4. Significant differences are seen in azo compound preferences for the two proteins, emphasizing the importance of the loop between strands beta3 and beta4 for azo ligand recognition; information on these loops is provided by the high-resolution (1.5 A) X-ray structure for avidin reported here. These results may be valuable in designing improved tools for avidin-based life science and nanobiotechnology applications.
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(as it appears on PubMed at http://www.pubmed.gov), where 17052607 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17052607}}
==About this Structure==
==About this Structure==
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[[Category: Biotin]]
[[Category: Biotin]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:55:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:21:14 2008''

Revision as of 16:21, 27 July 2008

Image:1vyo.png

Template:STRUCTURE 1vyo

CRYSTAL STRUCTURE OF AVIDIN

Template:ABSTRACT PUBMED 17052607

About this Structure

1VYO is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Binding properties of HABA-type azo derivatives to avidin and avidin-related protein 4., Repo S, Paldanius TA, Hytonen VP, Nyholm TK, Halling KK, Huuskonen J, Pentikainen OT, Rissanen K, Slotte JP, Airenne TT, Salminen TA, Kulomaa MS, Johnson MS, Chem Biol. 2006 Oct;13(10):1029-39. PMID:17052607

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