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2rcz

From Proteopedia

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{{STRUCTURE_2rcz| PDB=2rcz | SCENE= }}
{{STRUCTURE_2rcz| PDB=2rcz | SCENE= }}
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'''Structure of the second PDZ domain of ZO-1'''
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===Structure of the second PDZ domain of ZO-1===
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==Overview==
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ZO-1 is a multidomain protein involved in cell-cell junctions and contains three PDZ domains, which are necessary for its function in vivo. PDZ domains play a central role in assembling diverse protein complexes through their ability to recognize short peptide motifs on other proteins. We determined the structure of the second of the three PDZ domains of ZO-1, which is known to promote dimerization as well as bind to C-terminal sequences on connexins. The dimer is stabilized by extensive symmetrical domain swapping of beta-strands, which is unlike any other known mechanism of PDZ dimerization. The canonical peptide-binding groove remains intact in both subunits of the PDZ2 dimer and is created by elements contributed from both monomers. This unique structure reveals an additional example of how PDZ domains dimerize and has multiple implications for both peptide binding and oligomerization in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 17928286 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17928286}}
==About this Structure==
==About this Structure==
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[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
[[Category: Tight junction]]
[[Category: Tight junction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:39:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:24:23 2008''

Revision as of 16:24, 27 July 2008

Image:2rcz.png

Template:STRUCTURE 2rcz

Structure of the second PDZ domain of ZO-1

Template:ABSTRACT PUBMED 17928286

About this Structure

2RCZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Domain swapping within PDZ2 is responsible for dimerization of ZO proteins., Fanning AS, Lye MF, Anderson JM, Lavie A, J Biol Chem. 2007 Dec 28;282(52):37710-6. Epub 2007 Oct 9. PMID:17928286

Page seeded by OCA on Sun Jul 27 19:24:23 2008

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