2odl

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{{STRUCTURE_2odl| PDB=2odl | SCENE= }}
{{STRUCTURE_2odl| PDB=2odl | SCENE= }}
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'''Crystal structure of the HMW1 secretion domain from Haemophilus influenzae'''
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===Crystal structure of the HMW1 secretion domain from Haemophilus influenzae===
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==Overview==
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In pathogenic Gram-negative bacteria, many virulence factors are secreted via the two-partner secretion pathway, which consists of an exoprotein called TpsA and a cognate outer membrane translocator called TpsB. The HMW1 and HMW2 adhesins are major virulence factors in nontypeable Haemophilus influenzae and are prototype two-partner secretion pathway exoproteins. A key step in the delivery of HMW1 and HMW2 to the bacterial surface involves targeting to the HMW1B and HMW2B outer membrane translocators by an N-terminal region called the secretion domain. Here we present the crystal structure at 1.92 A of the HMW1 pro-piece (HMW1-PP), a region that contains the HMW1 secretion domain and is cleaved and released during HMW1 secretion. Structural analysis of HMW1-PP revealed a right-handed beta-helix fold containing 12 complete parallel coils and one large extra-helical domain. Comparison of HMW1-PP and the Bordetella pertussis FHA secretion domain (Fha30) reveals limited amino acid homology but shared structural features, suggesting that diverse TpsA proteins have a common structural domain required for targeting to cognate TpsB proteins. Further comparison of HMW1-PP and Fha30 structures may provide insights into the keen specificity of TpsA-TpsB interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17699157 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17699157}}
==About this Structure==
==About this Structure==
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[[Category: Hmw1]]
[[Category: Hmw1]]
[[Category: Secretion domain]]
[[Category: Secretion domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:40:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:24:41 2008''

Revision as of 16:24, 27 July 2008

Image:2odl.png

Template:STRUCTURE 2odl

Crystal structure of the HMW1 secretion domain from Haemophilus influenzae

Template:ABSTRACT PUBMED 17699157

About this Structure

2ODL is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

The structure of the Haemophilus influenzae HMW1 pro-piece reveals a structural domain essential for bacterial two-partner secretion., Yeo HJ, Yokoyama T, Walkiewicz K, Kim Y, Grass S, Geme JW 3rd, J Biol Chem. 2007 Oct 19;282(42):31076-84. Epub 2007 Aug 14. PMID:17699157

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