2iol

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{{STRUCTURE_2iol| PDB=2iol | SCENE= }}
{{STRUCTURE_2iol| PDB=2iol | SCENE= }}
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'''Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 1'''
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===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 1===
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==Overview==
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The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G. These interactions are mediated through two MA3 domains on the Pdcd4 molecule and result in inhibition of protein synthesis. We have solved the high-resolution crystal structure of the C-terminal MA3 (cMA3) domain of Pdcd4 in several crystal forms and demonstrated its similarity to the MA3 domain of eIF4G. As predicted by the structure, the cMA3 domain competes with eIF4Gc for binding to eIF4A and surprisingly is sufficient to inhibit translation initiation. Mutations that abolish eIF4A binding negate both functions of the cMA3. Interestingly mutations in the Akt phosphorylation site influenced neither cMA3 binding to eIF4A nor its ability to inhibit translation initiation. Finally, our structural analysis reveals MA3 domains to be a novel subfamily of VHS domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 17060447 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17060447}}
==About this Structure==
==About this Structure==
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: Alpha-helical]]
[[Category: Alpha-helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:43:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:25:30 2008''

Revision as of 16:25, 27 July 2008

Image:2iol.png

Template:STRUCTURE 2iol

Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 1

Template:ABSTRACT PUBMED 17060447

About this Structure

2IOL is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for inhibition of translation by the tumor suppressor Pdcd4., LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH, Mol Cell Biol. 2007 Jan;27(1):147-56. Epub 2006 Oct 23. PMID:17060447

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