2jxy

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{{STRUCTURE_2jxy| PDB=2jxy | SCENE= }}
{{STRUCTURE_2jxy| PDB=2jxy | SCENE= }}
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'''Solution structure of the hemopexin-like domain of MMP12'''
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===Solution structure of the hemopexin-like domain of MMP12===
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==Overview==
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The proteolytic activity of matrix metalloproteinases toward extracellular matrix components (ECM), cytokines, chemokines, and membrane receptors is crucial for several homeostatic and pathological processes. Active MMPs are a family of single-chain enzymes (23 family members in the human genome), most of which constituted by a catalytic domain and by a hemopexin-like domain connected by a linker. The X-ray structures of MMP-1 and MMP-2 suggest a conserved and well-defined spatial relationship between the two domains. Here we present structural data for MMP-12, suitably stabilized against self-hydrolysis, both in solution (NMR and SAXS) and in the solid state (X-ray), showing that the hemopexin-like and the catalytic domains experience conformational freedom with respect to each other on a time scale shorter than 10 (-8) s. Hints on the probable conformations are also obtained. This experimental finding opens new perspectives for the often hypothesized active role of the hemopexin-like domain in the enzymatic activity of MMPs.
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(as it appears on PubMed at http://www.pubmed.gov), where 18465858 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18465858}}
==About this Structure==
==About this Structure==
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2JXY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXY OCA].
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2JXY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXY OCA].
==Reference==
==Reference==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:12:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:28:00 2008''

Revision as of 16:28, 27 July 2008

Image:2jxy.png

Template:STRUCTURE 2jxy

Solution structure of the hemopexin-like domain of MMP12

Template:ABSTRACT PUBMED 18465858

About this Structure

2JXY is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Evidence of Reciprocal Reorientation of the Catalytic and Hemopexin-Like Domains of Full-Length MMP-12., Bertini I, Calderone V, Fragai M, Jaiswal R, Luchinat C, Melikian M, Mylonas E, Svergun DI, J Am Chem Soc. 2008 May 9;. PMID:18465858

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