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1s0p

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{{STRUCTURE_1s0p| PDB=1s0p | SCENE= }}
{{STRUCTURE_1s0p| PDB=1s0p | SCENE= }}
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'''Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum.'''
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===Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum.===
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==Overview==
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Cyclase-associated proteins (CAPs) are widely distributed and highly conserved proteins that regulate actin remodeling in response to cellular signals. The N termini of CAPs play a role in Ras signaling and bind adenylyl cyclase; the C termini bind to G-actin and thereby alter the dynamic rearrangements of the microfilament system. We report here the X-ray structure of the core of the N-terminal domain of the CAP from Dictyostelium discoideum, which comprises residues 51-226, determined by a combination of single isomorphous replacement with anomalous scattering (SIRAS). The overall structure of this fragment is an alpha helix bundle composed of six antiparallel helices. Results from gel filtration and crosslinking experiments for CAP(1-226), CAP(255-464), and the full-length protein, together with the CAP N-terminal domain structure and the recently determined CAP C-terminal domain structure, provide evidence that the functional structure of CAP is multimeric.
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(as it appears on PubMed at http://www.pubmed.gov), where 12962635 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12962635}}
==About this Structure==
==About this Structure==
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[[Category: Schleicher, M.]]
[[Category: Schleicher, M.]]
[[Category: Alpha helix bundle]]
[[Category: Alpha helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:09:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:36:58 2008''

Revision as of 16:37, 27 July 2008

Image:1s0p.png

Template:STRUCTURE 1s0p

Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum.

Template:ABSTRACT PUBMED 12962635

About this Structure

1S0P is a Single protein structure of sequence from Dictyostelium discoideum. This structure supersedes the now removed PDB entry 1pn1. Full crystallographic information is available from OCA.

Reference

Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum., Ksiazek D, Brandstetter H, Israel L, Bourenkov GP, Katchalova G, Janssen KP, Bartunik HD, Noegel AA, Schleicher M, Holak TA, Structure. 2003 Sep;11(9):1171-8. PMID:12962635

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