2ojq

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[[Image:2ojq.gif|left|200px]]
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{{STRUCTURE_2ojq| PDB=2ojq | SCENE= }}
{{STRUCTURE_2ojq| PDB=2ojq | SCENE= }}
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'''Crystal structure of Alix V domain'''
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===Crystal structure of Alix V domain===
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==Overview==
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The modular protein Alix is a central node in endosomal-lysosomal trafficking and the budding of human immunodeficiency virus (HIV)-1. The Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360-702. The structure of this fragment of Alix has the shape of the letter 'V' and is termed the V domain. The V domain has a topologically complex arrangement of 11 alpha-helices, with connecting loops that cross three times between the two arms of the V. The conserved residue Phe676 is at the center of a large hydrophobic pocket and is crucial for binding to a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1 release from cells. This inhibition of release is reversed by mutations that block binding of the Alix V domain to p6.
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(as it appears on PubMed at http://www.pubmed.gov), where 17277784 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17277784}}
==About this Structure==
==About this Structure==
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[[Category: Lee, S.]]
[[Category: Lee, S.]]
[[Category: Helical]]
[[Category: Helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:03:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:37:34 2008''

Revision as of 16:37, 27 July 2008

Image:2ojq.png

Template:STRUCTURE 2ojq

Crystal structure of Alix V domain

Template:ABSTRACT PUBMED 17277784

About this Structure

2OJQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for viral late-domain binding to Alix., Lee S, Joshi A, Nagashima K, Freed EO, Hurley JH, Nat Struct Mol Biol. 2007 Mar;14(3):194-9. Epub 2007 Feb 4. PMID:17277784

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