1rjh

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[[Image:1rjh.jpg|left|200px]]
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{{STRUCTURE_1rjh| PDB=1rjh | SCENE= }}
{{STRUCTURE_1rjh| PDB=1rjh | SCENE= }}
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'''Structure of the Calcium Free Form of the C-type Lectin-like Domain of Tetranectin'''
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===Structure of the Calcium Free Form of the C-type Lectin-like Domain of Tetranectin===
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==Overview==
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Tetranectin is a homotrimeric protein containing a C-type lectin-like domain. This domain (TN3) can bind calcium, but in the absence of calcium, the domain binds a number of kringle-type protein ligands. Two of the calcium-coordinating residues are also critical for binding plasminogen kringle 4 (K4). The structure of the calcium free-form of TN3 (apoTN3) has been determined by NMR. Compared to the structure of the calcium-bound form of TN3 (holoTN3), the core region of secondary structural elements is conserved, while large displacements occur in the loops involved in calcium or K4 binding. A conserved proline, which was found to be in the cis conformation in holoTN3, is in apoTN3 predominantly in the trans conformation. Backbone dynamics indicate that, in apoTN3 especially, two of the three calcium-binding loops and two of the three K4-binding residues exhibit increased flexibility, whereas no such flexibility is observed in holoTN3. In the 20 best nuclear magnetic resonance structures of apoTN3, the residues critical for K4 binding span a large conformational space. Together with the relaxation data, this indicates that the K4-ligand-binding site in apoTN3 is not preformed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15236571 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15236571}}
==About this Structure==
==About this Structure==
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1RJH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJH OCA].
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1RJH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJH OCA].
==Reference==
==Reference==
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[[Category: Tetranectin]]
[[Category: Tetranectin]]
[[Category: Trans proline]]
[[Category: Trans proline]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:34:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:42:23 2008''

Revision as of 16:42, 27 July 2008

Image:1rjh.png

Template:STRUCTURE 1rjh

Structure of the Calcium Free Form of the C-type Lectin-like Domain of Tetranectin

Template:ABSTRACT PUBMED 15236571

About this Structure

1RJH is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the plasminogen kringle 4 binding calcium-free form of the C-type lectin-like domain of tetranectin., Nielbo S, Thomsen JK, Graversen JH, Jensen PH, Etzerodt M, Poulsen FM, Thogersen HC, Biochemistry. 2004 Jul 13;43(27):8636-43. PMID:15236571

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