378d

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{{Seed}}
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{{STRUCTURE_378d| PDB=378d | SCENE= }}
{{STRUCTURE_378d| PDB=378d | SCENE= }}
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'''STRUCTURE OF THE SIDE-BY-SIDE BINDING OF DISTAMYCIN TO DNA'''
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===STRUCTURE OF THE SIDE-BY-SIDE BINDING OF DISTAMYCIN TO DNA===
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==Overview==
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The 2.40 A resolution crystal structure of a side-by-side binding of distamycin A molecules to a DNA octamer d(GTATATAC)2 with an extended alternating TA sequence has been determined. The unit-cell parameters are a = 29.55, b = 42.18, c = 43.38 A, beta = 96.56 degrees, space group P21, with two molecules in the asymmetric unit, in contrast to all previous side-by-side distamycin-DNA complexes which have only a single DNA strand and one drug molecule in the asymmetric unit. The structure was solved by the molecular-replacement method and refined to an R index of 21.0% using 3467 reflections [&gt;/= 2sigma(F)]. The minor grooves of the DNA molecules bind two side-by-side antiparallel staggered distamycins spanning about five base pairs and virtually covering the entire length of the DNA. The octamer duplexes exhibit low-high alternations in the helical twist, sugar puckering and the C-O3' and O3'-P torsion angles, similar to the earlier side-by-side complexes containing inosine bases. The molecules are stacked one over the other along the ac diagonal in an infinite pseudo-continuous helical column with no lateral interactions.
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The line below this paragraph, {{ABSTRACT_PUBMED_10089456}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10089456 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10089456}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Right handed dna]]
[[Category: Right handed dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:17:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:42:50 2008''

Revision as of 16:42, 27 July 2008

Image:378d.png

Template:STRUCTURE 378d

STRUCTURE OF THE SIDE-BY-SIDE BINDING OF DISTAMYCIN TO DNA

Template:ABSTRACT PUBMED 10089456

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the side-by-side binding of distamycin to d(GTATATAC)2., Mitra SN, Wahl MC, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 1999 Mar;55(Pt 3):602-9. PMID:10089456

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