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2a5t

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{{STRUCTURE_2a5t| PDB=2a5t | SCENE= }}
{{STRUCTURE_2a5t| PDB=2a5t | SCENE= }}
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'''Crystal Structure Of The NR1/NR2A ligand-binding cores complex'''
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===Crystal Structure Of The NR1/NR2A ligand-binding cores complex===
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==Overview==
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Excitatory neurotransmission mediated by NMDA (N-methyl-D-aspartate) receptors is fundamental to the physiology of the mammalian central nervous system. These receptors are heteromeric ion channels that for activation require binding of glycine and glutamate to the NR1 and NR2 subunits, respectively. NMDA receptor function is characterized by slow channel opening and deactivation, and the resulting influx of cations initiates signal transduction cascades that are crucial to higher functions including learning and memory. Here we report crystal structures of the ligand-binding core of NR2A with glutamate and that of the NR1-NR2A heterodimer with glutamate and glycine. The NR2A-glutamate complex defines the determinants of glutamate and NMDA recognition, and the NR1-NR2A heterodimer suggests a mechanism for ligand-induced ion channel opening. Analysis of the heterodimer interface, together with biochemical and electrophysiological experiments, confirms that the NR1-NR2A heterodimer is the functional unit in tetrameric NMDA receptors and that tyrosine 535 of NR1, located in the subunit interface, modulates the rate of ion channel deactivation.
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The line below this paragraph, {{ABSTRACT_PUBMED_16281028}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16281028 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16281028}}
==About this Structure==
==About this Structure==
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[[Category: Singh, S K.]]
[[Category: Singh, S K.]]
[[Category: Protein-ligand complex]]
[[Category: Protein-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:38:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:44:19 2008''

Revision as of 16:44, 27 July 2008

Image:2a5t.png

Template:STRUCTURE 2a5t

Crystal Structure Of The NR1/NR2A ligand-binding cores complex

Template:ABSTRACT PUBMED 16281028

About this Structure

2A5T is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Subunit arrangement and function in NMDA receptors., Furukawa H, Singh SK, Mancusso R, Gouaux E, Nature. 2005 Nov 10;438(7065):185-92. PMID:16281028

Page seeded by OCA on Sun Jul 27 19:44:19 2008

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