1n69

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{{STRUCTURE_1n69| PDB=1n69 | SCENE= }}
{{STRUCTURE_1n69| PDB=1n69 | SCENE= }}
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'''Crystal structure of human saposin B'''
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===Crystal structure of human saposin B===
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==Overview==
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Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from membranes, forming soluble protein-lipid complexes that are recognized by arylsulfatase A. The crystal structure of human saposin B reveals an unusual shell-like dimer consisting of a monolayer of alpha-helices enclosing a large hydrophobic cavity. Although the secondary structure of saposin B is similar to that of the known monomeric members of the saposin-like superfamily, the helices are repacked into a different tertiary arrangement to form the homodimer. A comparison of the two forms of the saposin B dimer suggests that extraction of target lipids from membranes involves a conformational change that facilitates access to the inner cavity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12518053 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12518053}}
==About this Structure==
==About this Structure==
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[[Category: Glycosphingolipid activator protein]]
[[Category: Glycosphingolipid activator protein]]
[[Category: Lipid binding protein]]
[[Category: Lipid binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:08:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:45:16 2008''

Revision as of 16:45, 27 July 2008

Image:1n69.png

Template:STRUCTURE 1n69

Crystal structure of human saposin B

Template:ABSTRACT PUBMED 12518053

About this Structure

1N69 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of saposin B reveals a dimeric shell for lipid binding., Ahn VE, Faull KF, Whitelegge JP, Fluharty AL, Prive GG, Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):38-43. Epub 2002 Dec 23. PMID:12518053

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