2hey

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[[Image:2hey.gif|left|200px]]
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{{Seed}}
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[[Image:2hey.png|left|200px]]
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{{STRUCTURE_2hey| PDB=2hey | SCENE= }}
{{STRUCTURE_2hey| PDB=2hey | SCENE= }}
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'''Crystal structure of murine OX40L bound to human OX40'''
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===Crystal structure of murine OX40L bound to human OX40===
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==Overview==
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OX40 is a T cell costimulator activated by OX40L. Blockade of the OX40L-OX40 interaction has ameliorative effects in animal models of T cell pathologies. In order to better understand the interaction between OX40 and OX40L, we have determined the crystal structure of murine OX40L and of the human OX40-OX40L complex at 1.45 and 2.4 A, respectively. These structures show that OX40L is an unusually small member of the tumor necrosis factor superfamily (TNFSF). The arrangement of the OX40L protomers forming the functional trimer is atypical and differs from that of other members by a 15 degrees rotation of each protomer with respect to the trimer axis, resulting in an open assembly. Site-directed changes of the interfacial residues of OX40L suggest this interface lacks a single "hot spot" and that instead, binding energy is dispersed over at least two distinct areas. These structures demonstrate the structural plasticity of TNFSF members and their interactions with receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_16905106}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16905106 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16905106}}
==About this Structure==
==About this Structure==
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[[Category: Receptor-ligan complex]]
[[Category: Receptor-ligan complex]]
[[Category: Tnfsf]]
[[Category: Tnfsf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:12:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:48:12 2008''

Revision as of 16:48, 27 July 2008

Image:2hey.png

Template:STRUCTURE 2hey

Crystal structure of murine OX40L bound to human OX40

Template:ABSTRACT PUBMED 16905106

About this Structure

2HEY is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the costimulatory OX40-OX40L complex., Compaan DM, Hymowitz SG, Structure. 2006 Aug;14(8):1321-30. PMID:16905106

Page seeded by OCA on Sun Jul 27 19:48:12 2008

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