1sgv

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{{STRUCTURE_1sgv| PDB=1sgv | SCENE= }}
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'''STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB)'''
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===STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB)===
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==Overview==
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The three-dimensional structure of the RNA-modifying enzyme, psi55 tRNA pseudouridine synthase from Mycobacterium tuberculosis, is reported. The 1.9-A resolution crystal structure reveals the enzyme, free of substrate, in two distinct conformations. The structure depicts an interesting mode of protein flexibility involving a hinged bending in the central beta-sheet of the catalytic module. Key parts of the active site cleft are also found to be disordered in the substrate-free form of the enzyme. The hinge bending appears to act as a clamp to position the substrate. Our structural data furthers the previously proposed mechanism of tRNA recognition. The present crystal structure emphasizes the significant role that protein dynamics must play in tRNA recognition, base flipping, and modification.
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(as it appears on PubMed at http://www.pubmed.gov), where 15028724 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15028724}}
==About this Structure==
==About this Structure==
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[[Category: Tbsgc]]
[[Category: Tbsgc]]
[[Category: Trna modification]]
[[Category: Trna modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:50:31 2008''

Revision as of 16:50, 27 July 2008

Image:1sgv.png

Template:STRUCTURE 1sgv

STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB)

Template:ABSTRACT PUBMED 15028724

About this Structure

1SGV is a Single protein structure of sequence from Mycobacterium tuberculosis. This structure supersedes the now removed PDB entry 1s71. Full crystallographic information is available from OCA.

Reference

Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft., Chaudhuri BN, Chan S, Perry LJ, Yeates TO, J Biol Chem. 2004 Jun 4;279(23):24585-91. Epub 2004 Mar 17. PMID:15028724

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