2oj9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2oj9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2oj9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2oj9| PDB=2oj9 | SCENE= }}
{{STRUCTURE_2oj9| PDB=2oj9 | SCENE= }}
-
'''Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor'''
+
===Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor===
-
==Overview==
+
<!--
-
The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the enzyme potency. SAR and biological activity of these compounds is presented.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17317169}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17317169 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17317169}}
==Disease==
==Disease==
Line 31: Line 35:
[[Category: Igf-1r]]
[[Category: Igf-1r]]
[[Category: Kinase domain]]
[[Category: Kinase domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:01:57 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:51:28 2008''

Revision as of 16:51, 27 July 2008

Template:STRUCTURE 2oj9

Contents

Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor

Template:ABSTRACT PUBMED 17317169

Disease

Known disease associated with this structure: Intrauterine and postnatal growth retardation OMIM:[147370]

About this Structure

2OJ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)., Velaparthi U, Wittman M, Liu P, Stoffan K, Zimmermann K, Sang X, Carboni J, Li A, Attar R, Gottardis M, Greer A, Chang CY, Jacobsen BL, Sack JS, Sun Y, Langley DR, Balasubramanian B, Vyas D, Bioorg Med Chem Lett. 2007 Apr 15;17(8):2317-21. Epub 2007 Feb 4. PMID:17317169

Page seeded by OCA on Sun Jul 27 19:51:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools