2df0

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[[Image:2df0.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2df0| PDB=2df0 | SCENE= }}
{{STRUCTURE_2df0| PDB=2df0 | SCENE= }}
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'''Solution structure of human PYY3-36'''
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===Solution structure of human PYY3-36===
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==Overview==
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PYY3-36 is a biopharmaceutical antiobesity agent under development as well as an endogenous satiety hormone, which is generated by dipeptidyl peptidase-IV digestion of polypetide YY (PYY), and in contrast to the parent hormone, PYY is highly selective for the Y2 versus the Y1 receptor. NMR analysis revealed a highly ordered, back-folded structure for human PYY in aqueous solution similar to the classical PP-fold structure of pancreatic polypeptide. The NMR analysis of PYY3-36 also showed a folded structure resembling a PP-fold, which however was characterized by far fewer long distance NOEs than the PP-fold observed in the full-length peptide. This suggests that either a conformational change has occurred in the N-terminal segment of PYY3-36 or that this segments is characterized by larger dynamics. The study supports the notion that the PP-fold is crucial for establishing simultaneous interactions with two subsites in the receptor for binding of, respectively, the N- and C-terminal ends of PYY. The Y2 receptor only requires recognition of the C-terminal segment of the molecule as displayed by the Y2 selective PYY3-36.
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The line below this paragraph, {{ABSTRACT_PUBMED_16819834}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16819834 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16819834}}
==About this Structure==
==About this Structure==
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2DF0 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DF0 OCA].
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2DF0 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DF0 OCA].
==Reference==
==Reference==
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[[Category: Pp-fold]]
[[Category: Pp-fold]]
[[Category: Pyy]]
[[Category: Pyy]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:18:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:53:25 2008''

Revision as of 16:53, 27 July 2008

Image:2df0.png

Template:STRUCTURE 2df0

Solution structure of human PYY3-36

Template:ABSTRACT PUBMED 16819834

About this Structure

2DF0 is a Single protein structure. Full experimental information is available from OCA.

Reference

The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR., Nygaard R, Nielbo S, Schwartz TW, Poulsen FM, Biochemistry. 2006 Jul 11;45(27):8350-7. PMID:16819834

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