1zpq

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[[Image:1zpq.gif|left|200px]]
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{{STRUCTURE_1zpq| PDB=1zpq | SCENE= }}
{{STRUCTURE_1zpq| PDB=1zpq | SCENE= }}
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'''STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein'''
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===STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein===
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==Overview==
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The tetrameric cII protein from bacteriophage lambda activates transcription from the phage promoters P(RE), P(I), and P(AQ) by binding to two direct repeats that flank the promoter -35 element. Here, we present the X-ray crystal structure of cII alone (2.8 A resolution) and in complex with its DNA operator from P(RE) (1.7 A resolution). The structures provide a basis for modeling of the activation complex with the RNA polymerase holoenzyme, and point to the key role for the RNA polymerase alpha subunit C-terminal domain (alphaCTD) in cII-dependent activation, which forms a bridge of protein/protein interactions between cII and the RNA polymerase sigma subunit. The model makes specific predictions for protein/protein interactions between cII and alphaCTD, and between alphaCTD and sigma, which are supported by previous genetic studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 16039594 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16039594}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transcription activation]]
[[Category: Transcription activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:55:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:58:53 2008''

Revision as of 16:58, 27 July 2008

Image:1zpq.png

Template:STRUCTURE 1zpq

STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein

Template:ABSTRACT PUBMED 16039594

About this Structure

1ZPQ is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

Crystal structure of bacteriophage lambda cII and its DNA complex., Jain D, Kim Y, Maxwell KL, Beasley S, Zhang R, Gussin GN, Edwards AM, Darst SA, Mol Cell. 2005 Jul 22;19(2):259-69. PMID:16039594

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