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2p3n

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[[Image:2p3n.gif|left|200px]]
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{{Seed}}
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[[Image:2p3n.png|left|200px]]
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{{STRUCTURE_2p3n| PDB=2p3n | SCENE= }}
{{STRUCTURE_2p3n| PDB=2p3n | SCENE= }}
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'''Thermotoga maritima IMPase TM1415'''
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===Thermotoga maritima IMPase TM1415===
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==Overview==
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The structure of the first tetrameric inositol monophosphatase (IMPase) has been solved. This enzyme, from the eubacterium Thermotoga maritima, similarly to its archaeal homologs exhibits dual specificity with both IMPase and fructose-1,6-bisphosphatase activities. The tetrameric structure of this unregulated enzyme is similar, in its quaternary assembly, to the allosterically regulated tetramer of fructose-1,6-bisphosphatase. The individual dimers are similar to the human IMPase. Additionally, the structures of two crystal forms of IMPase show significant differences. In the first crystal form, the tetrameric structure is symmetrical, with the active site loop in each subunit folded into a beta-hairpin conformation. The second form is asymmetrical and shows an unusual structural change. Two of the subunits have the active site loop folded into a beta-hairpin structure, whereas in the remaining two subunits the same loop adopts an alpha-helical conformation.
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The line below this paragraph, {{ABSTRACT_PUBMED_17419729}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17419729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17419729}}
==About this Structure==
==About this Structure==
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[[Category: Inositol]]
[[Category: Inositol]]
[[Category: Tetramer]]
[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:16:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:00:04 2008''

Revision as of 17:00, 27 July 2008

Image:2p3n.png

Template:STRUCTURE 2p3n

Thermotoga maritima IMPase TM1415

Template:ABSTRACT PUBMED 17419729

About this Structure

2P3N is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima., Stieglitz KA, Roberts MF, Li W, Stec B, FEBS J. 2007 May;274(10):2461-9. Epub 2007 Apr 10. PMID:17419729

Page seeded by OCA on Sun Jul 27 20:00:04 2008

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