2pe0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2pe0.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2pe0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2pe0| PDB=2pe0 | SCENE= }}
{{STRUCTURE_2pe0| PDB=2pe0 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX'''
+
===CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX===
-
==Overview==
+
<!--
-
HTS screening identified 1 with micromolar inhibitory activity against PDK1. Optimization of 1 afforded 4i (BX-517) which has single-digit nanomolar activity against PDK1 and excellent selectivity against PKA.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17531483}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17531483 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17531483}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Protein inhibitor complex]]
[[Category: Protein inhibitor complex]]
[[Category: Serine kinase]]
[[Category: Serine kinase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:56:18 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:01:52 2008''

Revision as of 17:01, 27 July 2008

Template:STRUCTURE 2pe0

CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX

Template:ABSTRACT PUBMED 17531483

About this Structure

2PE0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity., Islam I, Bryant J, Chou YL, Kochanny MJ, Lee W, Phillips GB, Yu H, Adler M, Whitlow M, Ho E, Lentz D, Polokoff MA, Subramanyam B, Wu JM, Zhu D, Feldman RI, Arnaiz DO, Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27. PMID:17531483

Page seeded by OCA on Sun Jul 27 20:01:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools