2auc

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{{STRUCTURE_2auc| PDB=2auc | SCENE= }}
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'''Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor'''
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===Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor===
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==Overview==
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The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.
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(as it appears on PubMed at http://www.pubmed.gov), where 16547135 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16547135}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomics of pathogenic protozoa consortium]]
[[Category: Structural genomics of pathogenic protozoa consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:29:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:02:13 2008''

Revision as of 17:02, 27 July 2008

Image:2auc.png

Template:STRUCTURE 2auc

Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor

Template:ABSTRACT PUBMED 16547135

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor., Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:16547135

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