1z01

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{{STRUCTURE_1z01| PDB=1z01 | SCENE= }}
{{STRUCTURE_1z01| PDB=1z01 | SCENE= }}
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'''2-Oxoquinoline 8-Monooxygenase Component: Active site Modulation by Rieske-[2fe-2S] Center Oxidation/Reduction'''
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===2-Oxoquinoline 8-Monooxygenase Component: Active site Modulation by Rieske-[2fe-2S] Center Oxidation/Reduction===
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==Overview==
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2-Oxoquinoline 8-monooxygenase is a Rieske non-heme iron oxygenase that catalyzes the NADH-dependent oxidation of the N-heterocyclic aromatic compound 2-oxoquinoline to 8-hydroxy-2-oxoquinoline in the soil bacterium Pseudomonas putida 86. The crystal structure of the oxygenase component of 2-oxoquinoline 8-monooxygenase shows a ring-shaped, C3-symmetric arrangement in which the mononuclear Fe(II) ion active site of one monomer is at a distance of 13 A from the Rieske-[2Fe-2S] center of a second monomer. Structural analyses of oxidized, reduced, and substrate bound states reveal the molecular bases for a new function of Fe-S clusters. Reduction of the Rieske center modulates the mononuclear Fe through a chain of conformational changes across the subunit interface, resulting in the displacement of Fe and its histidine ligand away from the substrate binding site. This creates an additional coordination site at the mononuclear Fe(II) ion and can open a pathway for dioxygen to bind in the substrate-containing active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 15893671 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15893671}}
==About this Structure==
==About this Structure==
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[[Category: Rieske center]]
[[Category: Rieske center]]
[[Category: Substrate bound complex]]
[[Category: Substrate bound complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:01:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:02:46 2008''

Revision as of 17:02, 27 July 2008

Image:1z01.png

Template:STRUCTURE 1z01

2-Oxoquinoline 8-Monooxygenase Component: Active site Modulation by Rieske-[2fe-2S] Center Oxidation/Reduction

Template:ABSTRACT PUBMED 15893671

About this Structure

1Z01 is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

2-Oxoquinoline 8-monooxygenase oxygenase component: active site modulation by Rieske-[2Fe-2S] center oxidation/reduction., Martins BM, Svetlitchnaia T, Dobbek H, Structure. 2005 May;13(5):817-24. PMID:15893671

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