2sbl

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{{STRUCTURE_2sbl| PDB=2sbl | SCENE= }}
{{STRUCTURE_2sbl| PDB=2sbl | SCENE= }}
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'''THE THREE-DIMENSIONAL STRUCTURE OF AN ARACHIDONIC ACID 15-LIPOXYGENASE'''
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===THE THREE-DIMENSIONAL STRUCTURE OF AN ARACHIDONIC ACID 15-LIPOXYGENASE===
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==Overview==
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In mammals, the hydroperoxidation of arachidonic acid by lipoxygenases leads to the formation of leukotrienes and lipoxins, compounds that mediate inflammatory responses. Lipoxygenases are dioxygenases that contain a nonheme iron and are present in many animal cells. Soybean lipoxygenase-1 is a single-chain, 839-residue protein closely related to mammalian lipoxygenases. The structure of soybean lipoxygenase-1 solved to 2.6 angstrom resolution shows that the enzyme has two domains: a 146-residue beta barrel and a 693-residue helical bundle. The iron atom is in the center of the larger domain and is coordinated by three histidines and the COO- of the carboxyl terminus. The coordination geometry is nonregular and appears to be a distorted octahedron in which two adjacent positions are not occupied by ligands. Two cavities, in the shapes of a bent cylinder and a frustum, connect the unoccupied positions to the surface of the enzyme. The iron, with two adjacent and unoccupied positions, is poised to interact with the 1,4-diene system of the substrate and with molecular oxygen during catalysis.
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The line below this paragraph, {{ABSTRACT_PUBMED_8502991}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8502991 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8502991}}
==About this Structure==
==About this Structure==
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[[Category: Boyington, J C.]]
[[Category: Boyington, J C.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:17:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:03:47 2008''

Revision as of 17:03, 27 July 2008

Image:2sbl.png

Template:STRUCTURE 2sbl

THE THREE-DIMENSIONAL STRUCTURE OF AN ARACHIDONIC ACID 15-LIPOXYGENASE

Template:ABSTRACT PUBMED 8502991

About this Structure

2SBL is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of an arachidonic acid 15-lipoxygenase., Boyington JC, Gaffney BJ, Amzel LM, Science. 1993 Jun 4;260(5113):1482-6. PMID:8502991

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