1ptr

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[[Image:1ptr.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ptr| PDB=1ptr | SCENE= }}
{{STRUCTURE_1ptr| PDB=1ptr | SCENE= }}
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'''PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE'''
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===PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE===
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==Overview==
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Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters. The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain. The C3, C4, and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation is controlled by a set of highly conserved residues. Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one-third of the domain, explaining how the activator promotes insertion of PKC into membranes.
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(as it appears on PubMed at http://www.pubmed.gov), where 7781068 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7781068}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, G.]]
[[Category: Zhang, G.]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:28:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:04:01 2008''

Revision as of 17:04, 27 July 2008

Image:1ptr.png

Template:STRUCTURE 1ptr

PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE

Template:ABSTRACT PUBMED 7781068

About this Structure

1PTR is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:7781068

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