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2ic9

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{{STRUCTURE_2ic9| PDB=2ic9 | SCENE= }}
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'''The Coiled-coil Domain (residues 1-93) Structure of the Sin Nombre Virus Nucleocapsid Protein'''
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===The Coiled-coil Domain (residues 1-93) Structure of the Sin Nombre Virus Nucleocapsid Protein===
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==Overview==
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Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule.
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{{ABSTRACT_PUBMED_17222867}}
==About this Structure==
==About this Structure==
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[[Category: Sin nombre virus]]
[[Category: Sin nombre virus]]
[[Category: Ssrna negative-strand viruse]]
[[Category: Ssrna negative-strand viruse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:19:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:07:18 2008''

Revision as of 17:07, 27 July 2008

Image:2ic9.png

Template:STRUCTURE 2ic9

The Coiled-coil Domain (residues 1-93) Structure of the Sin Nombre Virus Nucleocapsid Protein

Template:ABSTRACT PUBMED 17222867

About this Structure

2IC9 is a Single protein structure of sequence from Sin nombre virus. Full crystallographic information is available from OCA.

Reference

The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein., Boudko SP, Kuhn RJ, Rossmann MG, J Mol Biol. 2007 Mar 9;366(5):1538-44. Epub 2006 Dec 23. PMID:17222867

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