2qf5

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{{STRUCTURE_2qf5| PDB=2qf5 | SCENE= }}
{{STRUCTURE_2qf5| PDB=2qf5 | SCENE= }}
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'''High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)'''
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===High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)===
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==Overview==
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Bacterial cell shape is dictated by the cell wall, a plastic structure that must adapt to growth and division whilst retaining its function as a selectively permeable barrier. The modulation of cell wall structure is achieved by a variety of enzymatic functions, all of which must be spatially regulated in a precise manner. The membrane-spanning essential protein MreC has been identified as the central hub in this process, linking the bacterial cytoskeleton to a variety of cell wall-modifying enzymes. Additionally, MreC can form filaments, believed to run perpendicularly to the membrane. We present here the 1.2 A resolution crystal structure of the major periplasmic domain of Streptococcus pneumoniae MreC. The protein shows a novel arrangement of two barrel-shaped domains, one of which shows homology to a known protein oligomerization motif, with the other resembling a catalytic domain from a bacterial protease. We discuss the implications of these results for MreC function, and detail the structural features of the molecule that may be responsible for the binding of partner proteins.
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{{ABSTRACT_PUBMED_17707860}}
==About this Structure==
==About this Structure==
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[[Category: Filament a-lytic protease fold]]
[[Category: Filament a-lytic protease fold]]
[[Category: Structural protein]]
[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:51:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:09:03 2008''

Revision as of 17:09, 27 July 2008

Image:2qf5.png

Template:STRUCTURE 2qf5

High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (monoclinic form)

Template:ABSTRACT PUBMED 17707860

About this Structure

2QF5 is a Single protein structure of sequence from Streptococcus pneumoniae r6. Full crystallographic information is available from OCA.

Reference

High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC., Lovering AL, Strynadka NC, J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:17707860

Page seeded by OCA on Sun Jul 27 20:09:03 2008

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