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1zs8

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{{STRUCTURE_1zs8| PDB=1zs8 | SCENE= }}
{{STRUCTURE_1zs8| PDB=1zs8 | SCENE= }}
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'''Crystal Structure of the Murine MHC Class Ib Molecule M10.5'''
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===Crystal Structure of the Murine MHC Class Ib Molecule M10.5===
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==Overview==
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Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors. This interaction may play a direct role in the detection of pheromonal cues that initiate reproductive and territorial behaviors. The crystal structure of M10.5, an M10 family member, is similar to that of classical MHC molecules. However, the M10.5 counterpart of the MHC peptide-binding groove is open and unoccupied, revealing the first structure of an empty class I MHC molecule. Similar to empty MHC molecules, but unlike peptide-filled MHC proteins and non-peptide-binding MHC homologs, M10.5 is thermally unstable, suggesting that its groove is normally occupied. However, M10.5 does not bind endogenous peptides when expressed in mammalian cells or when offered a mixture of class I-binding peptides. The F pocket side of the M10.5 groove is open, suggesting that ligands larger than 8-10-mer class I-binding peptides could fit by extending out of the groove. Moreover, variable residues point up from the groove helices, rather than toward the groove as in classical MHC structures. These data suggest that M10s are unlikely to provide specific recognition of class I MHC-binding peptides, but are consistent with binding to other ligands, including proteins such as the V2Rs.
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{{ABSTRACT_PUBMED_16089503}}
==Disease==
==Disease==
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[[Category: Vomeronasal organ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:00:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:11:51 2008''

Revision as of 17:11, 27 July 2008

Image:1zs8.png

Template:STRUCTURE 1zs8

Contents

Crystal Structure of the Murine MHC Class Ib Molecule M10.5

Template:ABSTRACT PUBMED 16089503

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1ZS8 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a pheromone receptor-associated MHC molecule with an open and empty groove., Olson R, Huey-Tubman KE, Dulac C, Bjorkman PJ, PLoS Biol. 2005 Aug;3(8):e257. Epub 2005 Jul 12. PMID:16089503

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