1rsy

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{{STRUCTURE_1rsy| PDB=1rsy | SCENE= }}
{{STRUCTURE_1rsy| PDB=1rsy | SCENE= }}
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'''STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD'''
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===STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD===
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==Overview==
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C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-stranded beta sandwich constructed around a conserved four-stranded motif designated as a C2 key. Ca2+ binds in a cup-shaped depression between two polypeptide loops located at the N- and C-termini of the C2-key motif.
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(as it appears on PubMed at http://www.pubmed.gov), where 7697723 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7697723}}
==About this Structure==
==About this Structure==
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[[Category: Sutton, R B.]]
[[Category: Sutton, R B.]]
[[Category: Calcium/phospholipid binding protein]]
[[Category: Calcium/phospholipid binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:52:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:11:54 2008''

Revision as of 17:12, 27 July 2008

Image:1rsy.png

Template:STRUCTURE 1rsy

STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD

Template:ABSTRACT PUBMED 7697723

About this Structure

1RSY is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold., Sutton RB, Davletov BA, Berghuis AM, Sudhof TC, Sprang SR, Cell. 1995 Mar 24;80(6):929-38. PMID:7697723

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