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2j3r

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[[Image:2j3r.jpg|left|200px]]
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{{Seed}}
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[[Image:2j3r.png|left|200px]]
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{{STRUCTURE_2j3r| PDB=2j3r | SCENE= }}
{{STRUCTURE_2j3r| PDB=2j3r | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.'''
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===THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.===
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==Overview==
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Transport protein particle (TRAPP) I is a multisubunit vesicle tethering factor composed of seven subunits involved in ER-to-Golgi trafficking. The functional mechanism of the complex and how the subunits interact to form a functional unit are unknown. Here, we have used a multidisciplinary approach that includes X-ray crystallography, electron microscopy, biochemistry, and yeast genetics to elucidate the architecture of TRAPP I. The complex is organized through lateral juxtaposition of the subunits into a flat and elongated particle. We have also localized the site of guanine nucleotide exchange activity to a highly conserved surface encompassing several subunits. We propose that TRAPP I attaches to Golgi membranes with its large flat surface containing many highly conserved residues and forms a platform for protein-protein interactions. This study provides the most comprehensive view of a multisubunit vesicle tethering complex to date, based on which a model for the function of this complex, involving Rab1-GTP and long, coiled-coil tethers, is presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 17110339 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17110339}}
==About this Structure==
==About this Structure==
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[[Category: Trapp]]
[[Category: Trapp]]
[[Category: Vesicle transport]]
[[Category: Vesicle transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:17:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:14:52 2008''

Revision as of 17:14, 27 July 2008

Image:2j3r.png

Template:STRUCTURE 2j3r

THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.

Template:ABSTRACT PUBMED 17110339

About this Structure

2J3R is a Protein complex structure of sequences from Danio rerio and Mus musculus. Full crystallographic information is available from OCA.

Reference

The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering., Kim YG, Raunser S, Munger C, Wagner J, Song YL, Cygler M, Walz T, Oh BH, Sacher M, Cell. 2006 Nov 17;127(4):817-30. PMID:17110339

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