2owl

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[[Image:2owl.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2owl| PDB=2owl | SCENE= }}
{{STRUCTURE_2owl| PDB=2owl | SCENE= }}
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'''Crystal structure of E. coli RdgC'''
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===Crystal structure of E. coli RdgC===
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==Overview==
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The DNA-binding protein, RdgC, is associated with recombination and replication fork repair in Escherichia coli and with the virulence-associated, pilin antigenic variation mediated by RecA and other recombination proteins in Neisseria species. We solved the structure of the E. coli protein and refined it to 2.4A. RdgC crystallizes as a dimer with a head-to-head, tail-to-tail organization forming a ring with a 30 A diameter hole at the center. The protein fold is unique and reminiscent of a horseshoe with twin gates closing the open end. The central hole is lined with positively charged residues and provides a highly plausible DNA binding channel consistent with the nonspecific mode of binding detected in vitro and with the ability of RdgC to modulate RecA function in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 17308310 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17308310}}
==About this Structure==
==About this Structure==
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[[Category: Recombination]]
[[Category: Recombination]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:48:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:15:38 2008''

Revision as of 17:15, 27 July 2008

Image:2owl.png

Template:STRUCTURE 2owl

Crystal structure of E. coli RdgC

Template:ABSTRACT PUBMED 17308310

About this Structure

2OWL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Ring structure of the Escherichia coli DNA-binding protein RdgC associated with recombination and replication fork repair., Briggs GS, McEwan PA, Yu J, Moore T, Emsley J, Lloyd RG, J Biol Chem. 2007 Apr 27;282(17):12353-7. Epub 2007 Feb 16. PMID:17308310

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