1x8s

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{{STRUCTURE_1x8s| PDB=1x8s | SCENE= }}
{{STRUCTURE_1x8s| PDB=1x8s | SCENE= }}
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'''Structure of the Par-6 PDZ domain with a Pals1 internal ligand'''
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===Structure of the Par-6 PDZ domain with a Pals1 internal ligand===
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==Overview==
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PDZ protein interaction domains are typically selective for C-terminal ligands, but non-C-terminal, 'internal' ligands have also been identified. The PDZ domain from the cell polarity protein Par-6 binds C-terminal ligands and an internal sequence from the protein Pals1/Stardust. The structure of the Pals1-Par-6 PDZ complex reveals that the PDZ ligand-binding site is deformed to allow for internal binding. Whereas binding of the Rho GTPase Cdc42 to a CRIB domain adjacent to the Par-6 PDZ regulates binding of C-terminal ligands, the conformational change that occurs upon binding of Pals1 renders its binding independent of Cdc42. These results suggest a mechanism by which the requirement for a C terminus can be readily bypassed by PDZ ligands and reveal a complex set of cooperative and competitive interactions in Par-6 that are likely to be important for cell polarity regulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 15475968 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15475968}}
==About this Structure==
==About this Structure==
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[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Par-6]]
[[Category: Par-6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:42:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:18:28 2008''

Revision as of 17:18, 27 July 2008

Image:1x8s.png

Template:STRUCTURE 1x8s

Structure of the Par-6 PDZ domain with a Pals1 internal ligand

Template:ABSTRACT PUBMED 15475968

About this Structure

1X8S is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex., Penkert RR, DiVittorio HM, Prehoda KE, Nat Struct Mol Biol. 2004 Nov;11(11):1122-7. Epub 2004 Oct 10. PMID:15475968

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