2jby

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[[Image:2jby.gif|left|200px]]
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{{STRUCTURE_2jby| PDB=2jby | SCENE= }}
{{STRUCTURE_2jby| PDB=2jby | SCENE= }}
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'''A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO-SURVIVAL BCL-2'''
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===A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO-SURVIVAL BCL-2===
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==Overview==
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Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. Myxoma virus, a double-stranded DNA virus of the pox family, harbors antiapoptotic M11L, its virulence factor. Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. This allows it to associate with BH3 domains, especially those of Bax and Bak. We found that M11L acts primarily by sequestering Bax and Bak, thereby blocking the killing action of these essential cell-death mediators. These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak.
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(as it appears on PubMed at http://www.pubmed.gov), where 17386268 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17386268}}
==About this Structure==
==About this Structure==
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[[Category: Bcl-2 family]]
[[Category: Bcl-2 family]]
[[Category: Myxoma virus]]
[[Category: Myxoma virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:40:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:20:46 2008''

Revision as of 17:20, 27 July 2008

Image:2jby.png

Template:STRUCTURE 2jby

A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO-SURVIVAL BCL-2

Template:ABSTRACT PUBMED 17386268

About this Structure

2JBY is a Protein complex structure of sequences from Myxoma virus. Full crystallographic information is available from OCA.

Reference

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak., Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM, Mol Cell. 2007 Mar 23;25(6):933-42. PMID:17386268

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