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2if8

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{{STRUCTURE_2if8| PDB=2if8 | SCENE= }}
{{STRUCTURE_2if8| PDB=2if8 | SCENE= }}
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'''Crystal structure of Inositol Phosphate Multikinase Ipk2 in complex with ADP and Mn2+ from S. cerevisiae'''
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===Crystal structure of Inositol Phosphate Multikinase Ipk2 in complex with ADP and Mn2+ from S. cerevisiae===
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==Overview==
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Inositol polyphosphates perform essential functions as second messengers in eukaryotic cells, and their cellular levels are regulated by inositol phosphate kinases. Most of these enzymes belong to the inositol phosphate kinase superfamily, which consists of three subgroups, inositol 3-kinases, inositol phosphate multikinases, and inositol hexakisphosphate kinases. Family members share several strictly conserved signature motifs and are expected to have the same backbone fold, despite very limited overall amino acid sequence identity. Sequence differences are expected to play important roles in defining the different substrate selectivity of these enzymes. To investigate the structural basis for substrate specificity, we have determined the crystal structure of the yeast inositol phosphate multikinase Ipk2 in the apoform and in a complex with ADP and Mn(2+) at up to 2.0A resolution. The overall structure of Ipk2 is related to inositol trisphosphate 3-kinase. The ATP binding site is similar in both enzymes; however, the inositol binding domain is significantly smaller in Ipk2. Replacement of critical side chains in the inositolbinding site suggests how modification of substrate recognition motifs determines enzymatic substrate preference and catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 17050532 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17050532}}
==About this Structure==
==About this Structure==
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[[Category: Jogl, G.]]
[[Category: Jogl, G.]]
[[Category: Atp-grasp fold related]]
[[Category: Atp-grasp fold related]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:26:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:21:27 2008''

Revision as of 17:21, 27 July 2008

Image:2if8.png

Template:STRUCTURE 2if8

Crystal structure of Inositol Phosphate Multikinase Ipk2 in complex with ADP and Mn2+ from S. cerevisiae

Template:ABSTRACT PUBMED 17050532

About this Structure

2IF8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity., Holmes W, Jogl G, J Biol Chem. 2006 Dec 8;281(49):38109-16. Epub 2006 Oct 18. PMID:17050532

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