1tkx

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{{STRUCTURE_1tkx| PDB=1tkx | SCENE= }}
{{STRUCTURE_1tkx| PDB=1tkx | SCENE= }}
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'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''
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===CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745===
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==Overview==
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HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the X-ray crystal structure of inhibitors bound in the HIV-1 RT, a series of substituted 2-quinolones was synthesized and evaluated as HIV-1 inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 15537347 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15537347}}
==About this Structure==
==About this Structure==
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[[Category: Hiv-1 reverse transcriptase]]
[[Category: Hiv-1 reverse transcriptase]]
[[Category: Nnrti]]
[[Category: Nnrti]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:04:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:24:16 2008''

Revision as of 17:24, 27 July 2008

Image:1tkx.png

Template:STRUCTURE 1tkx

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745

Template:ABSTRACT PUBMED 15537347

About this Structure

1TKX is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2., Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH, J Med Chem. 2004 Nov 18;47(24):5923-36. PMID:15537347

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