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1t3d

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{{STRUCTURE_1t3d| PDB=1t3d | SCENE= }}
{{STRUCTURE_1t3d| PDB=1t3d | SCENE= }}
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'''Crystal structure of Serine Acetyltransferase from E.coli at 2.2A'''
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===Crystal structure of Serine Acetyltransferase from E.coli at 2.2A===
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==Overview==
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Serine acetyltransferase (SAT) catalyzes the first step of cysteine synthesis in microorganisms and higher plants. Here we present the 2.2 A crystal structure of SAT from Escherichia coli, which is a dimer of trimers, in complex with cysteine. The SAT monomer consists of an amino-terminal alpha-helical domain and a carboxyl-terminal left-handed beta-helix. We identify His(158) and Asp(143) as essential residues that form a catalytic triad with the substrate for acetyl transfer. This structure shows the mechanism by which cysteine inhibits SAT activity and thus controls its own synthesis. Cysteine is found to bind at the serine substrate site and not the acetyl-CoA site that had been reported previously. On the basis of the geometry around the cysteine binding site, we are able to suggest a mechanism for the O-acetylation of serine by SAT. We also compare the structure of SAT with other left-handed beta-helical structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 15231846 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15231846}}
==About this Structure==
==About this Structure==
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[[Category: Dimer of trimer]]
[[Category: Dimer of trimer]]
[[Category: Left-handed-beta-helix]]
[[Category: Left-handed-beta-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:28:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:24:44 2008''

Revision as of 17:24, 27 July 2008

Image:1t3d.png

Template:STRUCTURE 1t3d

Crystal structure of Serine Acetyltransferase from E.coli at 2.2A

Template:ABSTRACT PUBMED 15231846

About this Structure

1T3D is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure and mechanism of serine acetyltransferase from Escherichia coli., Pye VE, Tingey AP, Robson RL, Moody PC, J Biol Chem. 2004 Sep 24;279(39):40729-36. Epub 2004 Jul 1. PMID:15231846

Page seeded by OCA on Sun Jul 27 20:24:44 2008

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