2qkv

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{{STRUCTURE_2qkv| PDB=2qkv | SCENE= }}
{{STRUCTURE_2qkv| PDB=2qkv | SCENE= }}
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'''Crystal Structure of the C645S Mutant of the 5th PDZ Domain of InaD'''
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===Crystal Structure of the C645S Mutant of the 5th PDZ Domain of InaD===
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==Overview==
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The INAD scaffold organizes a multiprotein complex that is essential for proper visual signaling in Drosophila photoreceptor cells. Here we show that one of the INAD PDZ domains (PDZ5) exists in a redox-dependent equilibrium between two conformations--a reduced form that is similar to the structure of other PDZ domains, and an oxidized form in which the ligand-binding site is distorted through formation of a strong intramolecular disulfide bond. We demonstrate transient light-dependent formation of this disulfide bond in vivo and find that transgenic flies expressing a mutant INAD in which PDZ5 is locked in the reduced state display severe defects in termination of visual responses and visually mediated reflex behavior. These studies demonstrate a conformational switch mechanism for PDZ domain function and suggest that INAD behaves more like a dynamic machine rather than a passive scaffold, regulating signal transduction at the millisecond timescale through cycles of conformational change.
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{{ABSTRACT_PUBMED_17923089}}
==About this Structure==
==About this Structure==
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[[Category: Sensory transduction]]
[[Category: Sensory transduction]]
[[Category: Vision]]
[[Category: Vision]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:08:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:25:13 2008''

Revision as of 17:25, 27 July 2008

Image:2qkv.png

Template:STRUCTURE 2qkv

Crystal Structure of the C645S Mutant of the 5th PDZ Domain of InaD

Template:ABSTRACT PUBMED 17923089

About this Structure

2QKV is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Dynamic scaffolding in a g protein-coupled signaling system., Mishra P, Socolich M, Wall MA, Graves J, Wang Z, Ranganathan R, Cell. 2007 Oct 5;131(1):80-92. PMID:17923089

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